Acute pericarditis [published correction appears inReprinted with permission from Massachusetts Medical Society. However, treatments are available to decrease the duration of the condition and prevent recurrences. Developed in collaboration with the American Society of Echocardiography. A randomized trial of colchicine for acute pericarditis.
Colchicine was given at a dosage of 0.5 mg twice daily for three months in patients weighing more than 154 lb (70 kg) or 0.5 mg once daily in patients weighing 154 lb or less.
Current and future treatment for pericarditis. Glucocorticoid use during acute pericarditis confers a significant risk of adverse effects and possible recurrence of pericarditis (odds ratio = 4.30; 95% confidence interval, 1.21 to 15.25;
In: Braunwald E, Zipes DP, Libby P, eds.
Electrocardiographic manifestations and differential diagnosis of acute pericarditis. et al.
Trinchero R, Brucato A,
This is the noise of your pericardium rubbing against the outer layer of your heart.Treatment for pericarditis will depend on its underlying cause, if it’s known. Hoey ET, The usual therapy for people without other medical risks includes:If your pain is severe, your doctor may prescribe a stronger medication.Surgery may be considered in recurrent pericarditis that doesn’t respond to other treatment. Acute pericarditis is most common. Acute pericarditis is an inflammation of the pericardium characterized by chest pain, pericardial friction rub, and serial ECG changes. Healthline Media does not provide medical advice, diagnosis, or treatment. All rights reserved. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Clinical Application of Echocardiography). Detection of a pericardial rub on auscultation and 4. Trinchero R. First-line treatment includes nonsteroidal anti-inflammatory drugs and colchicine.
Additional laboratory testing and imaging are dictated by clinical presentation and risk factors.Transthoracic echocardiography should be performed in all patients with suspected acute pericarditis to exclude pericardial effusion and cardiac tamponade.Patients with acute pericarditis should be treated empirically with nonsteroidal anti-inflammatory drugs.Colchicine may be used as monotherapy or in combination with a nonsteroidal anti-inflammatory drug for the first episode of acute pericarditis.Evaluation of patients with acute pericarditis should include a history, physical examination, electrocardiography, chest radiography, and baseline laboratory studies (i.e., complete blood count, basic metabolic panel, troponin-I and creatine kinase levels, erythrocyte sedimentation rate, and serum C-reactive protein levels).
Prevalence of C-reactive protein elevation and time course of normalization in acute pericarditis: implications for the diagnosis, therapy, and prognosis of pericarditis. The first and … Spodick DH.
Imazio M, Controversial issues in the management of pericardial diseases. Acute pericarditis: diagnostic cues and common electrocardiographic manifestations. Diffuse concave ST-segment elevation and PR-segment depression are best demonstrated in leads I, II, aVL, and VAcute pericarditis electrocardiographic changes, stage 1.
All rights reserved. To see the full article, log in or purchase access.A = consistent, good-quality patient-oriented evidence; B = inconsistent or limited-quality patient-oriented evidence; C = consensus, disease-oriented evidence, usual practice, expert opinion, or case series.
For information about the SORT evidence rating system, go to Major predictors have been validated in multivariate analysisMajor predictors have been validated in multivariate analysisMost common or clinically important in each categoryAdapted with permission from Ariyarajah V, Spodick DH. et al. Chatterjee K,
Additional laboratory testing and imaging are dictated by clinical presentation and risk factors.Transthoracic echocardiography should be performed in all patients with suspected acute pericarditis to exclude pericardial effusion and cardiac tamponade.Patients with acute pericarditis should be treated empirically with nonsteroidal anti-inflammatory drugs.Colchicine may be used as monotherapy or in combination with a nonsteroidal anti-inflammatory drug for the first episode of acute pericarditis.Large pericardial effusion (an echo-free space greater than 20 mm)Nonsteroidal anti-inflammatory drug therapy ineffective after seven daysElevated cardiac troponin level (suggestive of myopericarditis)Large pericardial effusion (an echo-free space greater than 20 mm)Nonsteroidal anti-inflammatory drug therapy ineffective after seven daysElevated cardiac troponin level (suggestive of myopericarditis)Healthy pericardium consists of the inner serous visceral layer and the outer fibrous parietal layer that envelop the heart. Classic electrocardiographic changes include widespread concave upward ST-segment elevation without reciprocal T-wave inversions or Q waves. Seferović PM, Lange RA, Hillis LD.
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